张成
教授，博士生导师
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北京市青年教学名师
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联系方式
E-mail： chzhang2011@cnu.edu.cn
电 话：010-68903623（实验室）
中国·永利-www.yl23411.com|集团官网
研究方向： 生殖调控与信号传导
教育背景及工作经历：
1999.09—2003.06 宁夏大学动物医学专业（学士学位）
2003.09—2006.06 宁夏大学临床兽医学专业（硕士学位）
2007.09—2011.06 中国农业大学生理学专业（博士学位）
2008.09—2011.03 University of Ottawa（访问学者）
2011.08— yl23411永利集团官网
获奖情况：
1. 北京市高等学校青年教学名师 （2020）
2. 第47届国际生殖研究学会(SSR, USA) “国际最佳摘要奖”（2014）
3. 全国高校生命科学类微课教学比赛优秀制作奖（2019）
4. 首都师范大学优秀教师奖（2020）
5. 首都师范大学青年教师优秀教学奖（2017）
6. 首都师范大学优秀主讲教师（2018-2021）
7. 首都师范大学优秀指导教师（2015、2017、2018、2019、2021）
8. 首都师范大学青年标兵（2014、2019）
9. 首都师范大学优秀党支部书记（2019）
10. 首都师范大学优秀共产党员（2018）
11. 首都师范大学优秀班主任（2015）
12. 首都师范大学青年教师教学基本功竞赛最佳教案奖（2014）
13. 首都师范大学青年教师教学基本功竞赛二等奖（2014）
社会兼职：北京畜牧兽医学会理事
主要研究领域：
主要从事卵巢细胞增殖、分化的内分泌、旁分泌和自分泌调节和细胞信号传导机制的研究，尤其是关注甲状腺素调节卵泡发育的相关分子机理。另外，本实验室也在探索卵巢癌及多囊卵巢综合症(Polycystic ovarian syndrome, PCOS) 发病机理的相关研究。通过这些工作可使我们对卵泡发育，卵巢癌或多囊卵巢综合症等病理情况有更多认知，从而为人类生殖健康做出应有的贡献。
主要科研项目：
GRP78介导甲状腺素/促性腺激素调节大鼠卵泡发育的分子机制研究 [国家自然科学基金面上项目，主持]
NO介导甲状腺素调节大鼠卵泡发育机制的研究 [国家自然科学基金面上项目，主持]
甲状腺素/促性腺激素调节大鼠卵巢葡萄糖吸收机制的研究 [国家自然科学基金青年科学基金项目，主持]
OCT4介导甲状腺素调节小鼠卵泡发育机制的研究 [北京市自然科学基金面上项目，主持]
甲状腺素/促性腺激素调节小鼠腔前卵泡发育机制的研究 [北京市自然科学基金面上项目，主持]
甲状腺素调控大鼠卵巢细胞葡萄糖吸收机制的研究 [北京市留学回国人员择优资助项目，主持]
甲状腺素对大鼠卵泡细胞增殖、凋亡及PCOS卵巢作用机制的研究 [北京市优秀人才培养资助项目，主持]
T3/FSH调节大鼠卵巢Glut1-4表达机制的研究 [北京市教育委员会科技计划项目，主持]
家禽产业技术体系——蛋鸡营养与饲料 [北京市创新团队，主持—横向]
代表性论文：
1. Qiaozhi Wang, Yilin Yao, Xiaoshu Ma, Baoqiang Fu, Ningxin Li, Cheng Zhang*. Mechanisms of OCT4 on 3,5,3'-Tri-iodothyronine and FSH-induced Granulosa Cell Development in Female Mice. Endocrinology, 2021, 162(11): bqab183.
2. Qingyin Lin, Jiaqi Chen, Lifang Gu, Xingang Dan, Cheng Zhang*, Yanzhou Yang*. New insights into mitophagy and stem cells. Stem Cell Research & Therapy. 2021, 12(1):452.
3. Baoqiang Fu, YilinYao, Dai Heng, Ningxin Li, Xiaoshu Ma, Qiaozhi Wang, Yanzhou Yang, Cheng Zhang*. The Effect of Melatonin on OCT4 Expression and Granulosa Cell Growth in Female Mice. Reproductive Sciences. 2021, doi: 10.1007/s43032-021-00783-0.
4. Cheng Zhang, Yanping Liu, Jiliang Du, Han Liu, Shilun Zhu, Le Chen, Xuxin Wang, Xiushan Yang, Shen Tian. High-solid digestion from cellulosic ethanol stillage with activated sludge of simultaneous propionate degradation and methanogenesis. Bioresource Technology. 2021, 330:124951.
5. Dai Heng, Qiaozhi Wang, Xiaoshu Ma, Ye Tian, Kaili Xu, Xuechun Weng, Xusong Hu, Wenbo Liu, Cheng Zhang*.Role of OCT4 in theregulation of FSH-Induced Granulosa Cells Growth in Famale Mice. Frontiers in Endocinology. 2020, 10:915.
6. Kaili, Xu, Ye Tian, Xuechun Weng, Xusong Hu, Dai Heng, Guoliang Xia, Cheng Zhang*. Effect of thyroid dysfunction on NOS expression in the female rat. Cell and Tissue Research. 2020, 379(2):291-300.
7. Cheng Zhang*. The roles of different stem cells on premature ovarian failure. Current Stem Cell Research & Therapy. 2020;15(6):473-481. (Invited)
8. Qiaozhi Wang, Xiaoshu Ma, Cheng Zhang*. Effects of thyroid hormone on ovarian cell apoptosis in the rat. Reproduction Fertility and Development. 2020, 32(12):1060-1066.
9. Xiaoshu Ma, Xuechun Weng, Xusong Hu, Qiaozhi Wang, Ye Tian, Yu Ding, Cheng Zhang*. Roles of different n-3/n-6 PUFA ratios in ovarian cell development and steroidogenesis in PCOS rats. Food & Function. 2019, 10(11):7397-7406.
10. Xusong Hu, Xuechun Weng, Ye Tian, Chengtao Wang, Yanzhou Yang, Kaili Xu, Cheng Zhang*. Effects of omega-3 polyunsaturated fatty acids on steroidogenesis and cellular development in PCOS rats. Food & Function. 2019, 10(5):2504-2514.
11. Xuechun Weng, Xiaoshu Ma, Qiaozhi Wang, Kaili Xu, Xusong Hu, Wenbo Liu, Cheng Zhang*. Effect of hypothyroidism on CYP51 and FSHR expression in rat ovary. Theriogenology. 2019, 138:145-151.
12. Cheng Zhang, Qian Xue, Junyan Hou, Ali Mohsin, Mei Zhang, Meijin Guo, Yixuan Zhu, Jie Bao, Jingyu Wang, Wei Xiao, Limin Cao. In-Depth Two-Stage Transcriptional Reprogramming and Evolutionary Engineering of Saccharomyces cerevisiae for Efficient Bioethanol Production from Xylose with Acetate. Journal of Agricultural and Food Chemistry. 2019, 67(43):12002-12012.
13. Feng Wang, Xiaofang Ren, Zhen Chen, Xiaolong Li, Haijing Zhu, Li Sen, Xianghong Ou, Cheng Zhang, Feixiong Zhang, Baochang Zhu. The N-terminal His-tag affects the triglyceride lipase activity of hormone-sensitive lipase in testis. Journal of Cellular Biochemistry. 2019, 120(8):13706-13716.
14. Yanzhou Yang, Hoi-Hung Cheung, Cheng Zhang, Ji Wu, Wai-Yee Chan. Melatonin as potential targets for delaying ovarian aging. Current Drug Targets. 2019, 20(1):16-28.
15. Yingying Han, Fengwei Zhang, Fangzhou Suna, Haolin Zhang, Zhengrong Yuan, Cheng Zhang Qiang Weng. Toxicological effects of 3-methyl-4-nitrophenol on mouse ovarian and testicular cell proliferation, apoptosis and oocyte maturation. Reproductive Toxicology. 2018, 82:94-102.
16. Juan Liu, Meng Guo, Xusong Hu, Xuechun Weng, Ye Tian, Kaili Xu, Dai Heng, Wenbo Liu, Yu Ding, Yanzhou Yang, Cheng Zhang*. Effect of thyroid dysfunction on reproductive hormones in female rats. Chinese Journal of Physiology. 2018, 61(3):152-162.
17. Juan Liu, Yingying Han, Ye Tian, Xuechun Weng, Xusong Hu, Wenbo Liu, Dai Heng, Kaili Xu, Yanzhou Yang, Cheng Zhang*. Regulation by 3,5,3`-tri-iodothyronine and FSH of cytochrome P450 family 19 (CYP19) expression in mouse granulosa cells. Reproduction Fertility and Development. 2018, 30(9):1225-1233.
18. Ye Tian, Dai Heng, Kaili, Xu, Wenbo Liu, Xuechun Weng, Xusong Hu, Cheng Zhang*. cGMP/PKG-I pathway-mediated GLUT1/4 regulation by NO in female rat granulosa cells. Endocrinology. 2018, 159(2):1147-1158.
19. Juan Liu, Ye Tian, Yu Ding, Dai Heng, Kaili Xu, Wenbo Liu, Cheng Zhang*. Role of CYP51 in the regulation of T3 and FSH-induced steroidogenesis in female mice. Endocrinology. 2017, 158(11):1-14.
20. Ye Tian, Yu Ding, Juan Liu, Dai Heng, Kaili Xu, Wenbo Liu, Cheng Zhang*. NO-mediated regulation of Glut by T3 and FSH in rat granulosa cells. Endocrinology. 2017, 158(6):1-18.
21. Cheng Zhang*. Roles of Grp78 in female mammalian reproduction. Advances in Anatomy Embryology and Cell biology. 2017, 222:129-155. (Invited)
22. Dai Heng, Tao Zhang, Ye Tian, Shangyu Yu, Wenbo Liu, Kaili Xu, Juan Liu, Yu Ding, Baochang Zhu, Yanzhou Yang, Cheng Zhang*. Effects of dietary soybean isoflavones (SI) on reproduction in the young breeder rooster. Animal Reproduction Science. 2017, 177:124-131.
23. Meng Guo, Cheng Zhang, Yan Wang, Lizhao Feng, Zhengpin Wang, Wanbo Niu, Xiaoyan Du, Wang Tang, Yuna Li, Chao Wang Zhenwen Chen. Progesterone Receptor Membrane Component 1 Mediates Progesterone-Induced Suppression of Oocyte Meiotic Prophase I and Primordial. Scientific Reports. 2016, 6: 36869.
24. Ding Yu, Tian Ye, Guo Meng, Juan Liu, Dai Heng, Baochang Zhu, Yanzhou Yang, Cheng Zhang*. Regulation of glucose transport by thyroid hormone in rat ovary. Cell and Tissue Research. 2016, 366(2):455-466
25. Yanzhou Yang, Hoi Hung Cheung, Wai Nok Law, Cheng Zhang, Waiyee Chan, Xiuying Pei, Yanrong Wang. New insights into the role of autophagy in ovarian cryopreservation by vitrification. Biology of Reproduction. 2016, 94(6):137.
26. Yanzhou Yang, Xiuying Pei, Yaping Jin, Yanrong Wang, Cheng Zhang*. The roles of endoplasmic reticulum stress response in female mammalian reproduction. Cell and Tissue Research. 2016, 363(3):589-97.
27. Yun Feng, Yu Ding, Juan Liu, Ye Tian, Shuluan Guan, Yanzhou Yang, Cheng Zhang*. Effects of dietary omega-3/omega-6 fatty acid ratios on reproduction in the young breeder rooster. BMC Veterinary Research. 2015, 21; 11: 73.
28. Shuluan Guan , Li Guo, Tao Zhang, Baochang Zhu, Xiaoxia Wang, Cheng Zhang*. Effects of gonadotropin on Fas and/or FasL expression and proliferation in rat ovary. Theriogenology. 2015, 1; 83 (1):21-9.
编写教材：
主 编：
《人体及动物生理学实验》 高等教育出版社
《人体生理与人类生活》 高等教育出版社
《生理与生活》 高等教育出版社
副主编：
《动物生理学》 华中科技大学出版社 （国家十四五规划教材）
参 编：
《普通生物学》 华中科技大学出版社 （国家十四五规划教材）
《动物生理学》 华中科技大学出版社 （国家十二五规划教材）
《细胞生物学实验》 科学出版社（国家十一五规划教材）
《动物生理学》 高等教育出版社
《动物学》 科学出版社
《The role of heat shock proteins in reproductive system development and function》 Springer出版社