12月28日-青年学者生物学论坛-Histone Modifications and Mutations in DNA Mismatch Repair
题目：Histone Modifications and Mutations in DNA Mismatch Repair
报告人：李国民 教授
时间：2018年12月28日 下午2:00-3:00
地点：理科楼430
报告人简介:
李国民博士现为美国德克萨斯大学西南医学中心教授；德克萨斯大学西南医学中心直肠癌研究中心主任；美国科学促进会会士；担任Cell Research， JBC，DNA Repair, PLOS Genetics等多种学术刊物的编委；在包括Cell, Science, Mol. Cell, G&D, PNAS, eLIFE等学术刊物发表论文80多篇，是DNA错配修复和基因组稳定性研究领域的国际权威。
报告摘要:
DNA mismatch repair (MMR) ensures replication fidelity by correcting mismatches generated during DNA replication. Defects in MMR genes lead to a mutator phenotype and cancer development. Recent studies revealed that in addition to mutations in MMR genes, histone mutations and abnormal modifications also impair MMR function. In this presentation, I will discuss our recent studies on regulation of the MMR system by histone modifications and mutations, as well as their impact on cancer.